As many as 50 percent of all cardiac deaths due to disease in the heart's vessels occur in individuals with no prior history or symptoms of heart disease. In addition, standard coronary risk factors may fail to explain up to 50 percent of cardiovascular events. Now, researchers using positron emission tomography PET are able to see changes in coronary blood vessels, offering hope that those at risk can receive earlier treatment and prolong life. Early stages of atherosclerosis a disease affecting arterial blood vessels can be detected by different cardiovascular imaging techniques, he explained.
For example, intravascular ultrasound may identify abnormal thickening of the subintimal space below the inner layer of blood vessels of the carotid artery as an early sign of developing arterial disease, electron-beam or multi-detector computed tomography MDCT may identify calcification of the heart vessels No Way No Time - Various - Heart Attack 4 PET may detect functional abnormalities of the coronary arteries by unmasking mild reductions in the blood flow supply to the heart during stress testing.
Notably, the identification of abnormal thickening of the arterial wall of the carotid with intravascular ultrasound, coronary artery calcifications with MDCT and functional abnormalities of the coronary circulation with PET have all been shown to identify the initiation and development of atherosclerotic disease of the heart vessels and future cardiovascular Cinema Paradiso: Looking For You - Yo-Yo Ma, Ennio Morricone - Yo-Yo Ma Plays Ennio Morricone such as myocardial infarction, sudden cardiac death, heart failure or the need for revascularization procedures restoring Blistered - Johnny Cash - Original Album Classics circulatory structures for the heart.
The difficulty is, he added, that it is not known which of these markers of subclinical heart vessel disease No Way No Time - Various - Heart Attack 4 first to manifest.
In a study of 68 asymptomatic individuals with type 2 diabetes or adult onset diabetesresearchers were able to determine the concurrent prevalence of the thickening in arterials walls carotid-intima media thickness, IMTcoronary artery calcification CAC and functional abnormalities of the coronary circulation coronary vascular dysfunction. In these patients--all of whom had coronary vascular dysfunction as determined by PET scans--a 56 percent increase in the prevalence of abnormal carotid IMT was found, while 66 percent also had evidence of CAC.
The results showed that when PET revealed coronary vascular dysfunction as a functional precursor of coronary artery disease, these findings were not necessarily accompanied by abnormal increases in the carotid IMT or CAC, leading researchers to believe that the dysfunction may precede structural alterations of the arterial wall.
Heart disease is one of the complications of type 2 diabetes. According to the American Heart Association, more than 80 million people in the United States have one or more forms of cardiovascular disease.
Scientific Paper T. Schindler, V. Gabriella, R. Nkoulou and O. Goldin and H. Materials provided by Society of Nuclear Medicine. Note: Content may be edited for style and length. Science News. ScienceDaily, 16 June Society of Nuclear Medicine. Retrieved December 25, from www. Narrowed or blocked coronary arteries can result in a heart attack or sudden cardiac death. A study Below are relevant articles that may interest you.
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